Document Detail


Design of new anti-viral agents for chronic hepatitis B virus infection.
MedLine Citation:
PMID:  1751799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effectiveness of therapies for chronic hepatitis B will depend on their ability to inhibit all HBV replicative intermediates including viral SC DNA as well as stimulating the host's immune system to clear virus and produce sustained immunity. Future therapies will require the use of combined treatments in 'cocktail-type arrangements' as outlined in this paper, linked with careful staging of the hepatitis B carrier state.
Authors:
S Locarnini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  6 Suppl 1     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-27     Completed Date:  1992-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  18-22     Citation Subset:  IM    
Affiliation:
Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents* / therapeutic use
Drug Design*
Hepatitis B / drug therapy*
Hepatitis B virus / drug effects,  physiology
Hepatitis, Chronic / drug therapy*
Humans
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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