Document Detail


Design of a multicentre study on neurosonology in acute ischaemic stroke. A project of the neurosonology research group of the World Federation of Neurology.
MedLine Citation:
PMID:  12470856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report summarises the design and organisation of a multicentre study on neurosonology in acute ischaemic stroke. The Neurosonology in Acute Ischaemic Stroke Study will determine whether extracranial and transcranial Doppler and duplex sonography performed within 6 h after onset of stroke improves prediction of functional outcome if applied in addition to routine diagnostic admission investigations, i.e. medical history, standardised neurological examination, brain imaging by computed or magnetic resonance tomography, electrocardiography, and baseline laboratory examination. The primary hypothesis is that there is a consistent and persuasive difference between patients with an occluded middle cerebral artery and those with an open artery in terms of the functional deficit after 3 months. Power calculations are based on the assumption of alpha=0.05 (two-sided test) and a probability of a maximally mild functional deficit of 0.4. Detection of a 20% difference with a power of 0.8 resulted in a calculated sample of 400 patients to be observed. Calculation took into consideration that only 50% of admitted patients would have a moderate to severe neurological deficit of whom only 30% will have an occlusion of the corresponding middle cerebral artery. Furthermore, the study is designed to evaluate a difference of the functional outcome in relation to occurrence and time of recanalisation in-patients presenting with an initially occluded middle cerebral artery.
Authors:
Michael Goertler; Jens Allendoerfer; Gerhard-Michael von Reutern;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology     Volume:  16     ISSN:  0929-8266     ISO Abbreviation:  Eur J Ultrasound     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-09     Completed Date:  2003-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9440414     Medline TA:  Eur J Ultrasound     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany. michael.goertler@medizin.unimagdeburg.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Brain Ischemia / ultrasonography*
Female
Humans
Male
Middle Aged
Middle Cerebral Artery / ultrasonography*
Research Design*
Stroke / ultrasonography*
Ultrasonography, Doppler, Duplex
Ultrasonography, Doppler, Transcranial*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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