Document Detail

Design and function of transcriptional switches in Drosophila.
MedLine Citation:
PMID:  12225917     Owner:  NLM     Status:  MEDLINE    
Extensive genetic and biochemical analysis of Drosophila melanogaster has made this system an important model for characterization of transcriptional regulatory elements and factors. Given the striking conservation of transcriptional controls in metazoans, general principles derived from studies of Drosophila are expected to continue to illuminate transcriptional regulation in other systems, including vertebrates. With improvement in technologies for genetic manipulation of insects, research in Drosophila will also aid the design of systems for controlled expression of genes in other hosts. This review focuses on recent advances from Drosophila in analysis of the functional components of transcriptional switches, including basal promoters, enhancers, boundary elements, and maintenance elements.
D N Arnosti
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Insect biochemistry and molecular biology     Volume:  32     ISSN:  0965-1748     ISO Abbreviation:  Insect Biochem. Mol. Biol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-12     Completed Date:  2002-12-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9207282     Medline TA:  Insect Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1257-73     Citation Subset:  IM    
Michigan State University, Department of Biochemistry and Molecular Biology, East Lansing, MI 48824-1319, USA.
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MeSH Terms
Drosophila melanogaster / genetics*
Enhancer Elements, Genetic
Promoter Regions, Genetic
Transcription, Genetic*

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