Document Detail


Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib.
MedLine Citation:
PMID:  17878111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). The in vitro skin permeation profile of optimized formulations was compared with CXB gel and nanoemulsion gel. Significant increase in the steady state flux (Jss), permeability coefficient (Kp) and enhancement ratio (Er) was observed in nanoemulsion formulations T1 and T2 (p < 0.05). The highest value of these permeability parameters was obtained in formulation T2, which consisted of 2% (m/m) of CXB, 10% (m/m) of oil phase (Sefsol 218 and Triacetin), 50% (m/m) of surfactant mixture (Tween-80 and Transcutol-P) and 40% (m/m) water. The anti-inflammatory effects of formulation T2 showed a significant increase (p < 0.05) in inhibition after 24 h compared to CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of CXB.
Authors:
Sanjula Baboota; Faiyaz Shakeel; Alka Ahuja; Javed Ali; Sheikh Shafiq
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmaceutica (Zagreb, Croatia)     Volume:  57     ISSN:  1330-0075     ISO Abbreviation:  Acta Pharm     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303678     Medline TA:  Acta Pharm     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  315-32     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Analysis of Variance
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  chemistry,  pharmacokinetics
Carrageenan / administration & dosage,  toxicity
Drug Delivery Systems / methods*
Drug Design*
Drug Evaluation, Preclinical / methods
Drug Stability
Edema / chemically induced,  prevention & control
Emulsions
Gels
Hindlimb / drug effects,  pathology
Male
Microscopy, Electron, Transmission
Nanoparticles*
Particle Size
Pyrazoles / administration & dosage,  chemistry,  pharmacokinetics*
Rats
Rats, Wistar
Skin Absorption
Solubility
Sulfonamides / administration & dosage,  chemistry,  pharmacokinetics*
Viscosity
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Emulsions; 0/Gels; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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