| Design and development of curcumin bioconjugates as antiviral agents. | |
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MedLine Citation:
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PMID: 18776522 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A number of curcumin bioconjugates with fatty acid, dipeptide and folic acid, viz. di-O-decanoyl curcumin (2), di-O-tryptophanylphenylalanine curcumin (3), di-O-bis-(gamma, gamma)folyl curcumin (4), C(4)-ehyl-O-gamma-folyl curcumin (5) and 4-O-ethyl-O-gamma-folyl curcumin (6) have been synthesized. Conjugates 2-6 have shown good antiviral property with EC(50) ranging between 0.019-0.105 microM against a wide range of viruses, like HIV, HSV, VSV and many others. |
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Authors:
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Diwakar Rai; Dipti Yadav; J Balzarini; E De Clercq; Ramendra K Singh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2008 |
Date Detail:
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Created Date: 2008-09-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 599-600 Citation Subset: IM |
Affiliation:
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Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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