| Design of bioinspired polymeric materials based on poly(D,L-lactic acid) modifications towards improving its cytocompatibility. | |
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MedLine Citation:
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PMID: 17647223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To design novel bioinspired polymeric material, poly(D,L-lactic acid) (DL-PLA) was on the base and modified in the bulk. Firstly, maleic anhydride (MA) groups were introduced to the side chain of DL-PLA by the way of melting free radical copolymerization using benzoyl peroxide as an initiator. Then, to neutralize the acid generated during DL-PLA degradation, aliphatic diamine was immobilized by the N-acylation of anhydrides with butanediamine. As the following stage, adhesive peptides Arg-Gly-Asp-Ser (RGDS) were grafted into the backbone of DL-PLA by using carbodiimide as a coupling agent, in order to endow DL-PLA with bioactivity and biospecificity. The characterizations of the obtained polymers were by the means of GPC-MALLS, FTIR, (13)C NMR and XPS to explore the structures and rhodamine-carboxyl interaction method, ninhydrin reaction and amino acid analyzer to determine the content of MA, butanediamine, and RGDS, respectively, followed the test of pH changes during degradation in distilled water (pH = 6.45). Finally, the osteoblast behavior on different DL-PLA based films was investigated and the results indicated that the introduction of diamine could promote cell attachment and viability, and the incorporation of RGDS further improved its cytocompatibility. The synthetic DL-PLA based bioinspired material may have potentials for tissue engineering and other biomedical applications. |
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Authors:
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Xufeng Niu; Yanfeng Luo; Yonggang Li; Chunhua Fu; Jia Chen; Yuanliang Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 84 ISSN: 1552-4965 ISO Abbreviation: - Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-06-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 908-16 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley Periodicals, Inc. |
Affiliation:
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Research Center of Bioinspire Material Science and Engineering, Department of Bioengineering, Chongqing University, Chongqing 400030, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Butanes / chemistry Cell Adhesion Diamines / chemistry Hydrogen-Ion Concentration Lactic Acid / chemistry* Magnetic Resonance Spectroscopy Maleic Anhydrides / chemistry Microscopy, Electron, Scanning Osteoblasts / metabolism Polymers / chemistry* Rats Tissue Engineering / methods* Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Butanes; 0/Diamines; 0/Maleic Anhydrides; 0/Polymers; 106-97-8/butane; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 7732-18-5/Water |
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