| Design and baseline characteristics for the ACE Inhibitor After Anthracycline (AAA) study of cardiac dysfunction in long-term pediatric cancer survivors. | |
| | |
MedLine Citation:
|
PMID: 11579345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The ACE Inhibitor After Anthracycline (AAA) study is a randomized, double-blind, controlled clinical trial comparing enalapril with placebo to determine whether treatment can slow the progression of cardiac decline in patients who screen positive for anthracycline cardiotoxicity. METHODS: The primary outcome measure is the rate of decline, over time, in maximal cardiac index (in liters per minute per meters squared) at peak exercise; the secondary outcome measure is the rate of increase in left ventricular end systolic wall stress (in grams per centimeters squared). Patients >2 years off therapy and <4 years from diagnosis, aged 8 years and older, were eligible if they had received anthracyclines and had at least one cardiac abnormality identified at any time after anthracycline exposure. RESULTS: A total of 135 patients were randomized to enalapril or placebo. Baseline characteristics were similar across treatment groups. CONCLUSIONS: The AAA study will provide important information concerning the efficacy of using angiotensin-converting enzyme inhibitors to offset the effects of late anthracycline cardiotoxicity. |
| | |
Authors:
|
J H Silber; A Cnaan; B J Clark; S M Paridon; A J Chin; J Rychik; A N Hogarty; M I Cohen; G Barber; M Rutkowsky; T R Kimball; C Delaat; L J Steinherz; H Zhao; M R Tartaglione |
Related Documents
:
|
8800725 - University of wisconsin solution versus stanford cardioplegic solution and the developm... 20103775 - The effects of vitamin d supplementation on physical function and quality of life in ol... 20525985 - Impact of erythropoiesis-stimulating agents on morbidity and mortality in patients with... 16290975 - Pilot study to determine the impact of a multidisciplinary educational intervention in ... 22406775 - Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled ... 23241665 - Short- and medium-term impact of a residential weight-loss camp for overweight adolesce... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American heart journal Volume: 142 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2001 Oct |
Date Detail:
|
Created Date: 2001-10-01 Completed Date: 2001-12-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
|
Languages: eng Pagination: 577-85 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pediatric Oncology, Department of Pediatrics, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Silber@email.chop.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Algorithms Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Anthracyclines / adverse effects*, therapeutic use Child Child, Preschool Disease Progression Double-Blind Method Enalapril / adverse effects, therapeutic use* Female Heart Diseases / chemically induced*, diagnosis, prevention & control* Heart Function Tests Humans Infant Male Neoplasms / drug therapy* Placebos Research Design / standards Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
|
CA-16520/CA/NCI NIH HHS; M01-RR-00240/RR/NCRR NIH HHS; R01 HL-50424/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Anthracyclines; 0/Placebos; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Seven cases of surgical native valve endocarditis caused by coagulase-negative staphylococci: An und...
Next Document: Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-o...