| Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator. | |
| | |
MedLine Citation:
|
PMID: 15642569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This report presents the rationale and study design details of the SHock Inhibition Evaluation with Azimilide study, which is recruiting 624 patients with implantable cardioverter-defibrillators (ICDs) who are at risk for life-threatening ventricular arrhythmia, randomized to azimilide 75 mg, azimilide 125 mg, or placebo and followed for 1 year. The objective of this study is to determine the effect of azimilide versus placebo on the symptomatic ventricular arrhythmia burden using a unique statistical analysis based on the unusual temporal distribution of symptomatic ICD therapies. The primary efficacy end points are time to all-cause shocks and time to all-cause shocks plus symptomatic ventricular arrhythmic events triggering antitachycardia pacing measured from randomization. |
| | |
Authors:
|
Craig M Pratt; Paul Dorian; Hussein R Al-Khalidi; Jose M Brum; Martin Borggrefe; Daljit S Tatla; Johannes Brachmann; Robert J Myerburg; David S Cannom; Michael J Holroyde; Michael van der Laan; Stefan H Hohnloser; |
Related Documents
:
|
18930369 - Shoshin beriberi mimicking a high-risk non-st-segment elevation acute coronary syndrome... 971019 - Surgical correction of cardiogenic shock. 300989 - Treatment of cardiogenic shock in myocardial infarction by intraaortic balloon counterp... 9249849 - Alternating current electrocution detection and termination by an implantable cardiover... 10981859 - 'tako-tsubo' transient ventricular dysfunction: a case report. 16484919 - Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pa... 12125669 - Early- and long-term comparison of the on- and off-pump bypass surgery in patients with... 19178129 - Management of angina pectoris: the role of spinal cord stimulation. 973899 - Clinical experience with technetium-99m stannous polyphosphate for myocardial imaging. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of cardiology Volume: 95 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2005-01-11 Completed Date: 2005-02-17 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 274-6 Citation Subset: AIM; IM |
Affiliation:
|
The Methodist DeBakey Heart Center and the Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA. cpratt@bcm.tmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Arrhythmia Agents
/
administration & dosage* Defibrillators, Implantable* Double-Blind Method Drug Administration Schedule Humans Imidazolidines / administration & dosage* Piperazines / administration & dosage* Randomized Controlled Trials as Topic* Research Design Tachycardia, Ventricular / drug therapy, therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 0/Imidazolidines; 0/Piperazines; 149888-94-8/azimilide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence of adequate control of increased serum low-density lipoprotein cholesterol in self-pay or...
Next Document: Refeeding normalizes the QT rate dependence of female anorexic patients.