Document Detail


Design optimization of a mechanical heart valve for reducing valve thrombogenicity-A case study with ATS valve.
MedLine Citation:
PMID:  20613492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients implanted with mechanical heart valves (MHV) or with ventricular assist devices that use MHV require mandatory lifelong anticoagulation for secondary stroke prevention. We recently developed a novel Device Thrombogenicity Emulator (DTE) methodology that interfaces numerical and experimental approaches to optimize the thrombogenic performance of the device and reduce the bleeding risk associated with anticoagulation therapy. Device Thrombogenicity Emulator uses stress-loading waveforms in pertinent platelet flow trajectories that are extracted from highly resolved numerical simulations and emulates these flow conditions in a programmable hemodynamic shearing device (HSD) by which platelet activity is measured. We have previously compared two MHV, ATS and the St. Jude Medical, and demonstrated that owing to its nonrecessed hinge design, the ATS valve offers improved thrombogenic performance. In this study, we further optimize the ATS valve thrombogenic performance, by modifying various design features of the valve, intended to achieve reduced thrombogenicity: 1) optimizing the leaflet-housing gap clearance; 2) increasing the effective maximum opening angle of the valve; and 3) introducing a streamlined channel between the leaflet stops of the valve that increases the effective flow area. We have demonstrated that the DTE optimization methodology can be used as test bed for developing devices with significantly improved thombogenic performance.
Authors:
Yared Alemu; Gaurav Girdhar; Michalis Xenos; Jawaad Sheriff; Jolyon Jesty; Shmuel Einav; Danny Bluestein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  56     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-02     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-96     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Stony Brook University, New York 11794-8181, USA.
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Heart Valve Prosthesis* / adverse effects
Hemodynamics / physiology*
Models, Cardiovascular
Models, Theoretical*
Prosthesis Design / instrumentation*,  methods*
Shear Strength
Thrombosis / prevention & control*
Grant Support
ID/Acronym/Agency:
1R01 EB008004-01/EB/NIBIB NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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