Document Detail


Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar.
MedLine Citation:
PMID:  22551299     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several novel nucleoside analogues as potential inhibitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via selective coupling of an appropriate nucleobase at different positions of an orthogonally protected imino sugar as a common precursor. This synthetic strategy offers a straightforward protocol for the assembly of imino sugar containing nucleosides, establishing a new repertoire of molecules as potential therapeutics.
Authors:
Saúl Martı́nez-Montero; Susana Fernández; Yogesh S Sanghvi; Jyoti Chattopadhyaya; Muthupandian Ganesan; Namakkal G Ramesh; Vicente Gotor; Miguel Ferrero
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-2
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departamento de Quı́mica Orgánica e Inorgánica and Instituto Universitario de Biotecnologı́a de Asturias, Universidad de Oviedo , 33006 Oviedo (Asturias), Spain.
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