Document Detail


The Design of Dextran-Based Hypoxia-Inducible Hydrogels via In Situ Oxygen-Consuming Reaction.
MedLine Citation:
PMID:  25303104     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypoxia plays a critical role in the development and wound healing process, as well as a number of pathological conditions. Here, dextran-based hypoxia-inducible (Dex-HI) hydrogels formed with in situ oxygen consumption via a laccase-medicated reaction are reported. Oxygen levels and gradients were accurately predicted by mathematical simulation. It is demonstrated that Dex-HI hydrogels provide prolonged hypoxic conditions up to 12 h. The Dex-HI hydrogel offers an innovative approach to delineate not only the mechanism by which hypoxia regulates cellular responses, but may facilitate the discovery of new pathways involved in the generation of hypoxic and oxygen gradient environments.
Authors:
Kyung Min Park; Michael R Blatchley; Sharon Gerecht
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-9
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  -     ISSN:  1521-3927     ISO Abbreviation:  Macromol Rapid Commun     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-10     Completed Date:  -     Revised Date:  2014-10-11    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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