| Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. | |
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MedLine Citation:
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PMID: 20923989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent genome-wide association studies (GWAS) of myocardial infarction (MI) and other forms of coronary artery disease (CAD) have led to the discovery of at least 13 genetic loci. In addition to the effect size, power to detect associations is largely driven by sample size. Therefore, to maximize the chance of finding novel susceptibility loci for CAD and MI, the Coronary ARtery DIsease Genome-wide Replication And Meta-analysis (CARDIoGRAM) consortium was formed. METHODS AND RESULTS: CARDIoGRAM combines data from all published and several unpublished GWAS in individuals with European ancestry; includes >22 000 cases with CAD, MI, or both and >60 000 controls; and unifies samples from the Atherosclerotic Disease VAscular functioN and genetiC Epidemiology study, CADomics, Cohorts for Heart and Aging Research in Genomic Epidemiology, deCODE, the German Myocardial Infarction Family Studies I, II, and III, Ludwigshafen Risk and Cardiovascular Heath Study/AtheroRemo, MedStar, Myocardial Infarction Genetics Consortium, Ottawa Heart Genomics Study, PennCath, and the Wellcome Trust Case Control Consortium. Genotyping was carried out on Affymetrix or Illumina platforms followed by imputation of genotypes in most studies. On average, 2.2 million single nucleotide polymorphisms were generated per study. The results from each study are combined using meta-analysis. As proof of principle, we meta-analyzed risk variants at 9p21 and found that rs1333049 confers a 29% increase in risk for MI per copy (P=2×10⁻²⁰). CONCLUSION: CARDIoGRAM is poised to contribute to our understanding of the role of common genetic variation on risk for CAD and MI. |
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Authors:
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Michael Preuss; Inke R König; John R Thompson; Jeanette Erdmann; Devin Absher; Themistocles L Assimes; Stefan Blankenberg; Eric Boerwinkle; Li Chen; L Adrienne Cupples; Alistair S Hall; Eran Halperin; Christian Hengstenberg; Hilma Holm; Reijo Laaksonen; Mingyao Li; Winfried März; Ruth McPherson; Kiran Musunuru; Christopher P Nelson; Mary Susan Burnett; Stephen E Epstein; Christopher J O'Donnell; Thomas Quertermous; Daniel J Rader; Robert Roberts; Arne Schillert; Kari Stefansson; Alexandre F R Stewart; Gudmar Thorleifsson; Benjamin F Voight; George A Wells; Andreas Ziegler; Sekar Kathiresan; Muredach P Reilly; Nilesh J Samani; Heribert Schunkert; |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-05 |
Journal Detail:
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Title: Circulation. Cardiovascular genetics Volume: 3 ISSN: 1942-3268 ISO Abbreviation: Circ Cardiovasc Genet Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-01-31 Revised Date: 2011-08-04 |
Medline Journal Info:
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Nlm Unique ID: 101489144 Medline TA: Circ Cardiovasc Genet Country: United States |
Other Details:
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Languages: eng Pagination: 475-83 Citation Subset: IM |
Affiliation:
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Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Coronary Artery Disease / genetics* Female Genetic Predisposition to Disease* Genome-Wide Association Study* Genotype Humans Male Middle Aged Myocardial Infarction / genetics Polymorphism, Single Nucleotide Research Design* |
| Grant Support | |
ID/Acronym/Agency:
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HL087647/HL/NHLBI NIH HHS; MOP172605//Canadian Institutes of Health Research; MOP77682//Canadian Institutes of Health Research; MOP82810//Canadian Institutes of Health Research; R01 HL089650-02/HL/NHLBI NIH HHS; R01HL089650-02/HL/NHLBI NIH HHS; U54 RR020278/RR/NCRR NIH HHS; //British Heart Foundation; //Medical Research Council; //Wellcome Trust |
| Investigator | |
Investigator/Affiliation:
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Heribert Schunkert / ; Nilesh J Samani / ; Sekar Kathiresan / ; Muredach P Reilly / ; Jeanette Erdmann / ; Eric Boerwinkle / ; Jeanette Erdmann / ; Alistair Hall / ; Christian Hengstenberg / ; Sekar Kathiresan / ; Inke R König / ; Reijo Laaksonen / ; Ruth McPherson / ; Themistocles L Assimes / ; Muredach P Reilly / ; Nilesh J Samani / ; Heribert Schunkert / ; John R Thompson / ; Unnur Thorsteinsdottir / ; Andreas Ziegler / ; Inke R König / ; John R Thompson / ; Devin Absher / ; Li Chen / ; L Adrienne Cupples / ; Eran Halperin / ; Mingyao Li / ; Kiran Musunuru / ; Michael Preuss / ; Arne Schillert / ; Gudmar Thorleifsson / ; Benjamin F Voight / ; George A Wells / |
| Comments/Corrections | |
Comment In:
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Circ Cardiovasc Genet. 2010 Oct;3(5):396-8
[PMID:
20959590
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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