| Design considerations for pulsed-flow comprehensive two-dimensional GC: dynamic flow model approach. | |
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MedLine Citation:
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PMID: 20412645 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GCxGC) system is described. The dynamic flow model assists design of a PFM-GCxGC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GCxGC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GCxGC system. The flexibility of a PFM-GCxGC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods. |
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Authors:
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Paul McA Harvey; Robert A Shellie; Paul R Haddad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatographic science Volume: 48 ISSN: 1945-239X ISO Abbreviation: J Chromatogr Sci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173225 Medline TA: J Chromatogr Sci Country: United States |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: - |
Affiliation:
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Australian Centre for Research on Separation Science, University of Tasmania, Private Bag 75, Hobart, 7001, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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