| Desensitization of the post-synaptic membrane of neuromuscular synapses induced by spontaneous quantum secretion of mediator. | |
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MedLine Citation:
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PMID: 9762720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments on isolated frog neuromuscular junctions in voltage-clamped conditions demonstrated increases in the probability of spontaneous release of quanta of mediator, resulting in increases in the K+ ion concentration in the perfusion solution, and changes in the endplate miniature current amplitude induced by increased quantum generation were studied. Factors promoting the desensitization of the post-synaptic cholinergic membrane (inhibition of acetylcholinesterase and addition of proadifen) to levels greater than a certain (critical) frequency of endplate miniature current of the order of 50 spikes/sec were found to result in accumulation of activity and progressive reductions in the sensitivity of the post-synaptic membrane to the mediator acetylcholine. |
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Authors:
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R A Giniatullin; L G Magazanik |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience and behavioral physiology Volume: 28 ISSN: 0097-0549 ISO Abbreviation: Neurosci. Behav. Physiol. Publication Date: 1998 Jul-Aug |
Date Detail:
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Created Date: 1998-12-21 Completed Date: 1998-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330471 Medline TA: Neurosci Behav Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 438-42 Citation Subset: IM |
Affiliation:
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Department of Normal Physiology, Kazan' State Medical University, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism,
physiology* Acetylcholinesterase / metabolism Animals Anura Cholinesterase Inhibitors / pharmacology Enzyme Inhibitors / pharmacology Motor Endplate / drug effects, physiology Muscle, Skeletal / innervation, physiology Neuromuscular Junction / drug effects, metabolism, physiology* Patch-Clamp Techniques Potassium / pharmacology Proadifen / pharmacology Sciatic Nerve / cytology, drug effects, physiology Stimulation, Chemical Synaptic Membranes / drug effects, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Enzyme Inhibitors; 302-33-0/Proadifen; 51-84-3/Acetylcholine; 7440-09-7/Potassium; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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