Document Detail

Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
MedLine Citation:
PMID:  3035615     Owner:  NLM     Status:  MEDLINE    
The activation of rat polymorphonuclear leukocytes (PMN) with PAF-acether (platelet-activating factor) was blocked by two antagonists: 48740 RP and BN 52021. The release of beta glucuronidase was usually better inhibited than that of lysozyme suggesting that the tested antagonists interfere rather with PAF-acether exocytosis of azurophil granules. Inhibition was relatively specific, even though a moderate effect (below 34%) upon PMN activation by the two unrelated agonist n-formyl-Methionyl-Leucyl-Phenylalanine (fMLP) and leukotriene B4 sometimes reached significance. The partial persistence of inhibition to stimulation with PAF-acether after elimination of both inhibitors suggests that they do not act at the PAF-acether receptor only. Furthermore, the observation of cross desensitization between PAF-acether and fMLP may be related to common pathways and/or metabolites, including PAF-acether itself.
M Bureau; D Joseph; B B Vargaftig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  33     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-07-01     Completed Date:  1987-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-50     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Cytochalasin B / pharmacology
Exocytosis / drug effects
Glucuronidase / blood
Leukotriene B4 / pharmacology
Muramidase / blood
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / enzymology,  physiology*
Plant Extracts / pharmacology
Platelet Activating Factor / antagonists & inhibitors,  physiology*
Pyridines / pharmacology
Rats, Inbred Strains
Thiazoles / pharmacology
Reg. No./Substance:
0/Diterpenes; 0/Ginkgolides; 0/Lactones; 0/Plant Extracts; 0/Platelet Activating Factor; 0/Pyridines; 0/Thiazoles; 14930-96-2/Cytochalasin B; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 71160-24-2/Leukotriene B4; 93363-11-2/3-(3-pyridinyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide; 99796-69-7/ginkgolide B; EC; EC

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