Document Detail

Descriptive study of chronic calcific pancreatitis in Sri Lanka.
MedLine Citation:
PMID:  15881556     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe the potential risk factors, clinical features, biochemical and radiological features, and management of chronic calcific pancreatitis. DESIGN: Cross-sectional descriptive study. SETTING: Tertiary care general hospital. PATIENTS: Fifty patients with pancreatic calcification referred to the Colombo South Teaching Hospital, and 50 age-matched controls from healthy relatives or friends of the patients. MEASUREMENT: Height and weight measurements, immunoreactive insulin levels and trypsin levels of duodenal aspirates were estimated. Plain abdominal xray and ultrasonography were performed. INTERVENTION: Endoscopic retrograde cholangiopancreaticography (ERCP) was attempted on all patients during which duodenal aspirates were collected. Success rates of ERCP and response to endotherapeutic procedures were recorded. RESULTS: Twenty two of the 50 chronic calcific pancreatitis (CP) patients were diagnosed to have chronic alcoholic calcific pancreatitis (CACP). Mean age of the CACP patients was significantly higher than that of the chronic calcific pancreatitis of the tropics (CCPT) patients. Severe malnutrition (BMI < 20), frequent consumption of Manihot esculenta (manioc, cassava) and a high consumption of chilli or pepper were identified as possible risk factors for both alcoholic and non-alcoholic CP. Onset of diabetes occurred at a much younger age in the CCPT group than in the CACP group. Mean serum insulin was significantly higher in the CCPT group than in the CACP group and duodenal trypsin level was significantly lower in the CCPT than in CACP group. CONCLUSIONS: Our results confirm the existence of both alcoholic (CACP) and non-alcoholic (CCPT) types of chronic calcific pancreatitis in Sri Lanka. A larger study is required to confirm the associated risk factors such as Manihot esculenta and foods with a high content of chilli or pepper.
Mohan de Silva; Siva Selliah; Ira Thabrew
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Ceylon medical journal     Volume:  50     ISSN:  0009-0875     ISO Abbreviation:  Ceylon Med J     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264702     Medline TA:  Ceylon Med J     Country:  Sri Lanka    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Faculty of Medical Sciences, University of Sri Jayawardenepura, Nugegoda, Sri Lanka.
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MeSH Terms
Calcinosis / diagnosis,  epidemiology*
Cholangiopancreatography, Endoscopic Retrograde
Chronic Disease
Cross-Sectional Studies
Hospitals, Teaching
Middle Aged
Pancreatitis / diagnosis,  epidemiology*
Pancreatitis, Alcoholic / diagnosis,  epidemiology
Risk Factors
Sri Lanka / epidemiology

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