Document Detail


Description of a novel panallergen of cross-reactivity between moulds and foods.
MedLine Citation:
PMID:  16698676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present investigation is undertaken to demonstrate a novel cross-reactivity between aeroallergens (moulds fungi imperfecti) and allergens from foods (spinach and mushroom Agaricus bisporus). We have performed a dual study in vivo and in vitro, in a population of atopic patients. Data from in vivo tests performed with spinach and mushroom have been statistically analysed. To the in vitro assays, mushroom and spinach extracts have been obtained, and sera from moulds allergic patients analysed by means of IgE-immunoblott assays. Inhibition experiments have been also performed to study a possible relation between proteins. Statistical analysis of data showed a relation between allergenicity to moulds (Alternaria alternata, Cladosporium herbarum and/or Aspergillus fumigatus), and positive skin prick tests with mushroom and/or spinach. The immunoblotts performed showed that seven moulds allergic patients had a strong recognition of a protein with a molecular weight of about 30 kD present both in spinach and mushroom extracts, and by means of inhibition assays we could determine that these two proteins were related. This study demonstrates the existence of a new allergen responsible for cross reactivity between moulds and two frequently consumed foods, mushroom and spinach. We conclude that a novel cross-reactive allergen between aeroallergens and foods has been identified.
Authors:
Inmaculada Herrera-Mozo; Beatriz Ferrer; Jose Luís Rodriguez-Sanchez; Cándido Juarez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunological investigations     Volume:  35     ISSN:  0882-0139     ISO Abbreviation:  Immunol. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8504629     Medline TA:  Immunol Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-97     Citation Subset:  IM    
Affiliation:
Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. inmaculadahm@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Agaricus / immunology*
Allergens / adverse effects,  immunology*
Child
Child, Preschool
Cross Reactions
Female
Food Hypersensitivity / blood,  immunology,  microbiology*
Humans
Hypersensitivity, Immediate / blood,  etiology*,  immunology,  microbiology
Immunoblotting
Immunoglobulin E / blood,  immunology
Male
Mitosporic Fungi / immunology*
Skin Tests
Spinacia oleracea / adverse effects,  immunology*
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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