| Description of a new kind of MHC DNA sequence in Saguinus oedipus (cotton-top tamarin). | |
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MedLine Citation:
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PMID: 9777328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The MHC class I genes of the New World primate the cotton-top tamarin (Saguinus oedipus) are an exception to the high polymorphism and variability usually displayed by this multigene family. In the present work, the cloning and sequencing of a new pseudogene, tentatively named Saoe-Mhc-N4, in this primate species are reported. This new sequence has two characteristic deletions at exon 2, making it very unlikely that any putative protein from this sequence was an antigen-presenting molecule. Comparison of intron 1, intron 2, partial exon 1, exon 2 and partial exon 3 showed little similarity with those of classical class I genes and pseudogenes in S. oedipus and in other primates. Phylogenetic analysis grouped this Saoe-Mhc-N4 sequence with other pseudogenes in S. oedipus. Thus, it seems that Saoe-Mhc-N4 is an inactivated gene or a pseudogene which has been originated by the common process of duplication and subsequent inactivation of MHC class I loci in this primate species. |
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Authors:
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M Alvarez; J Martínez-Laso; C García-Torre; P Varela; M Pérez-Blas; M A Moreno; E Gómez-Casado; A Arnaiz-Villena |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics Volume: 25 ISSN: 0960-7420 ISO Abbreviation: Eur. J. Immunogenet. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-11-30 Completed Date: 1998-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9106962 Medline TA: Eur J Immunogenet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
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Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U83202 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Base Sequence Cloning, Molecular DNA* Evolution, Molecular Genes, MHC Class I* Molecular Sequence Data Phylogeny Pseudogenes* Saguinus / classification, genetics* |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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