Document Detail

Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004).
MedLine Citation:
PMID:  19178669     Owner:  NLM     Status:  MEDLINE    
Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant of feline lymphoma. Limited information exists in the literature regarding pathological and immunohistochemical descriptions, clinical findings, treatment and survival times. The purpose of this study was to describe clinical features, treatment and outcome in feline LGL lymphoma. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. Decreased appetite/anorexia, weight loss, lethargy and vomiting were the most commonly reported clinical signs. All cats tested for feline leukaemia virus and feline immunodeficiency virus infection were negative. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis.
E L Krick; L Little; R Patel; F S Shofer; K Sorenmo; C A Clifford; J L Baez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary and comparative oncology     Volume:  6     ISSN:  1476-5829     ISO Abbreviation:  Vet Comp Oncol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2009-01-30     Completed Date:  2009-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185242     Medline TA:  Vet Comp Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-10     Citation Subset:  IM    
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Cat Diseases / drug therapy,  pathology*
Immunohistochemistry / veterinary
Lymphoma / drug therapy,  pathology,  veterinary*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy,  pathology,  veterinary*
Retrospective Studies
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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