Document Detail

Des-gamma-carboxyprothrombin (PIVKA-II) levels in maternal serum throughout gestation.
MedLine Citation:
PMID:  16052408     Owner:  NLM     Status:  MEDLINE    
The status of vitamin K in pregnant women was investigated using the highly sensitive method for des-gamma-carboxyprothrombin (protein induced by vitamin K absence [PIVKA-II]), electrochemiluminescence immunoassay. A gradual elevation of PIVKA-II related to gestational weeks was observed in healthy pregnant women, suggesting that a modest vitamin K deficiency takes place in gestation. Furthermore, throughout gestation the majority of pregnant women exceeded the healthy adult levels in PIVKA-II. Among complicated gestations of preeclampsia, a remarkable elevation of PIVKA-II was observed in severe preeclampsia, in which a high correlation between PIVKA-II level and coagulation parameters, including thrombin-antithrombin (TAT) complexes, was revealed. These data were suggestive that the vitamin K status readily decreased into a deficient status in hypercoagulative conditions. Among other complicated gestations, a moderate elevation of PIVKA-II was demonstrated in hyperemetic conditions, and, if at all, only a slight elevation of PIVKA-II was observed in other maternal diseases. The present study is the first report regarding the changes of PIVKA-II in pregnant women.
Tomizo Nishiguchi; Kaoru Matsuyama; Takao Kobayashi; Naohiro Kanayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  31     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-29     Completed Date:  2005-10-18     Revised Date:  2006-03-07    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Assistant Professor, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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MeSH Terms
Biological Markers / blood*
Chemiluminescent Measurements
Gestational Age
Pre-Eclampsia / blood
Protein Precursors / blood*
Thrombophilia / blood
Vitamin K / blood
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 12001-79-5/Vitamin K; 53230-14-1/acarboxyprothrombin; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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