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Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells.
MedLine Citation:
PMID:  22799321     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The use of herbal products as radiosensitizers is a promising approach to increase the efficacy of radiotherapy. However, adverse effects related to the use of herbal medicine on radiotherapy are not well characterized. The present study concerns the impact of Derris scandens Benth extract on the radiosensitivity of Hep-2 laryngeal cancer cells. Pretreatment with D. scandens extract prior to gamma irradiation significantly increased clonogenic survival and decreased the proportion of radiation-induced abnormal nuclei of Hep-2 cells. Furthermore, the extract was found to enhance radiation-induced G2/M phase arrest, induce Akt activation, and increase motility of Hep-2 cells. The study thus indicated that D. scandens extract potentiates radioresistance of Hep-2 cells, further demonstrating the importance of cellular background for the adverse effect of D. scandens extract on radiation response in a laryngeal cancer cell line.
Authors:
Arunee Hematulin; Sutiwan Meethang; Kornkanok Ingkaninan; Daniel Sagan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  13     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1289-95     Citation Subset:  IM    
Affiliation:
Department of Radiation Technology, Faculty of Allied Health Science, Naresuan University, Phitsanulok, Thailand E-mail : hematulin_a@yahoo.com, aruneeh@nu.ac.th.
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