Document Detail

Dermatopathology of the foreskin: an institutional experience of over 400 cases.
MedLine Citation:
PMID:  23106553     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under-recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology.
METHODS: Diagnoses rendered on foreskin specimens between 1982 and April 2009 were obtained through a computer-based keyword search. Cases given normal, non-specific or descriptive diagnoses were reviewed by a dermatopathologist.
RESULTS: Keyword search yielded 414 foreskin diagnoses. Interpretations included normal foreskin (n = 131), benign lesions (n = 262) and malignant/dysplastic entities (n = 21). Of 353 cases given normal, descriptive or non-specific diagnoses, 334 were reviewed. Of reviewed cases, 209 (63%) were given more specific diagnoses [e.g. spongiotic dermatitis (n = 115), lichen sclerosus et atrophicus (LSA; n = 41), interface/lichenoid dermatitis (n = 26), psoriasiform dermatitis (n = 7)]. Discrepancy between the clinical and pathologic impression was frequently noted (n = 77).
CONCLUSIONS: This study shows benign inflammatory lesions represent the most frequent foreskin pathology. When possible, specific diagnoses should be rendered, as accurate classification may be of clinical importance. There is an abundance of recent literature on the role of circumcision in disease prevention, and this topic is explored. We discuss the theoretical possibility that foreskin inflammation compromises the mucosal/epithelial barrier, thus playing a role in disease transmission.
Dava S West; John A Papalas; Maria A Selim; Robin T Vollmer
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Publication Detail:
Type:  Journal Article     Date:  2012-10-25
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  40     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-13     Revised Date:  2014-05-26    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons A/S.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*,  surgery
Child, Preschool
Circumcision, Male
Condylomata Acuminata / pathology,  surgery
Databases, Factual
Dermatitis / pathology*,  surgery
Foreskin / pathology*,  surgery
Infant, Newborn
Lichen Sclerosus et Atrophicus / pathology*,  surgery
Middle Aged
Neoplasms / pathology,  surgery
Phimosis / pathology,  surgery
Psoriasis / pathology*,  surgery
Retrospective Studies
Skin Neoplasms / pathology*,  surgery
Young Adult
Comment In:
J Urol. 2014 May;191(5):1319-21   [PMID:  24745499 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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