| Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study. | |
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MedLine Citation:
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PMID: 23330740 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: While the chronic inflammation related to autoimmune diseases is known to be associated with an increased cardiovascular risk, much less is known about cerebrovascular risks. The present population-based, age- and sex-matched follow-up study was undertaken to investigate the risks of acute myocardial infarction (AMI) and ischaemic stroke in patients with dermatomyositis (DMS). METHODS: A total of 907 patients with DMS were enrolled, and compared with a non-DMS control group consisting of 4535 age- and sex-matched, randomly sampled subjects without DMS. The AMI-free and ischaemic stroke-free survival curves were generated using the Kaplan-Meier method. Cox proportional hazard regression was used to estimate the DMS-associated risks of AMI and ischaemic stroke. RESULTS: During the two-year follow-up period, 14 DMS patients (1.5%) and 18 in the non-DMS control group (0.4%) suffered AMIs. The crude hazard ratio (HR) for suffering an AMI in DMS patients compared to subjects in the non-DMS group was 3.96 (95% CI: 1.97-7.96, P = 0.0001), while the adjusted HR was 3.37 (95% CI, 1.67-6.80; P = 0.0007), after taking into account demographic characteristics and cardiovascular comorbidities. During the same follow-up period, 46 patients (5.1%) and 133 in the non-DMS control group (2.9%) developed ischaemic strokes. The crude HR for developing an ischaemic stroke in DMS patients compared to subjects in the non-DMS group was 1.78 (95% confidence interval [CI]: 1.27 -2.49, P = 0.0007), and the adjusted HR was 1.67 (95% CI, 1.19 - 2.34; P = 0.0028). CONCLUSIONS: These findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events. |
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Authors:
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Y-T Lai; Y-S Dai; M-F Yen; L-S Chen; H-H Chen; R G Cooper; S-L Pan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©The Authors BJD © 2013 British Association of Dermatologists. |
Affiliation:
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Department of Physical Medicine and Rehabilitation, Cathay General Hospital, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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