Document Detail


Dermatomyositis associated with impairment in both muscle aerobic and anaerobic function.
MedLine Citation:
PMID:  15696782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a 50-year-old Japanese woman with dermatomyositis in whom an anti-mitochondrial antibody was detected. Muscle biopsy demonstrated periodic acid Schiff- (PAS) positive vacuoles in addition to infiltrates of mononuclear cells. Histochemical analysis showed reduced phosphorylase activity. An aerobic exercise test demonstrated that the concentrations of serum lactate and pyruvate were elevated before corticosteroid therapy but decreased after the therapy. On the other hand, in forearm ischemic exercise tests, the responses of serum lactate and pyruvate were attenuated before corticosteroid therapy but recovered after the therapy. These findings indicate that an inflammatory mechanism interfered with myophosphorylase activity and muscle aerobic function.
Authors:
M Kunishige; T Mitsui; I Endo; T Matsumoto
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  24     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Affiliation:
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Anaerobiosis
Autoantibodies / analysis
Dermatomyositis / blood,  drug therapy,  immunology,  pathology,  physiopathology*
Exercise*
Exercise Test
Female
Humans
Lactic Acid / blood
Middle Aged
Mitochondria / immunology
Muscle, Skeletal / enzymology,  immunology,  pathology,  physiopathology*
Phosphorylases / metabolism
Pyruvic Acid / blood
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Autoantibodies; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; EC 2.4.1.-/Phosphorylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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