Document Detail

Dermatological presentation of disease associated with antineutrophil cytoplasmic antibodies: a report of two contrasting cases and a review of the literature.
MedLine Citation:
PMID:  8736337     Owner:  NLM     Status:  MEDLINE    
Antineutrophil cytoplasmic antibody (ANCA)-associated disease (AAD) constitutes a pathological disease spectrum of a necrotizing vasculitis of small- and medium-sized vessels, extravascular granuloma formation, and necrotizing and crescentic glomerulonephritis, and also a clinical disease continuum which ranges from renal-limited disease to a widespread systemic vasculitis, including Wegener's granulomatosis and microscopic polyangiitis. In the latter, circulating ANCA are an aid to diagnosis and also may play a pathogenic part. Two contrasting patients with AAD are described, both of whom presented primary with dermatological features. These included a cutaneous purpuric vasculitis, orogenital ulceration, infarction of the fingertip, and pyoderma gangrenosum-like ulceration. These cases will familiarize dermatologists with both the concept and dermatological features of AAD.
A D Irvine; I N Bruce; M Walsh; D Burrows; J Handley
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The British journal of dermatology     Volume:  134     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  924-8     Citation Subset:  IM    
Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies / analysis*
Autoimmune Diseases / immunology*,  pathology
Fingers / blood supply
Infarction / immunology
Middle Aged
Purpura, Schoenlein-Henoch / immunology
Pyoderma Gangrenosum / immunology
Skin Diseases / immunology*,  pathology
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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