Document Detail

Dermatological manifestations in primary biliary cirrhosis patients: a case control study.
MedLine Citation:
PMID:  16464228     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Primary biliary cirrhosis (PBC), a disease of probable autoimmune etiology that affects the small intrahepatic bile ducts of mainly middle-aged women is commonly associated with pruritus, xanthomatous lesions, and melanosis. We conducted a prospective study to systematically describe the skin disorders of a group of PBC patients. METHODS: A prospective evaluation and analysis of dermatological manifestations including oral and genital lesions was carried out, in 49 PBC patients (45 females and 4 males). Median age 63 yr (range 35-87 yr). They were compared with 45 age and sex matched controls, selected among persons attending the dermatologic outpatient clinic. RESULTS: A total of 330 skin disorders were found in the 49 PBC patients versus 76 in the 45 controls; 31.5% of all lesions were skin fungal infections. Of all lesions analyzed with the Bonferroni rule of multiple comparisons significantly more common in PBC patients were plantar mycoses, onychomycoses, and interdigital mycoses. Pruritus was found in 69.3% of patients versus 22.2% of controls, xerosis in 69.3%versus 2.2%, dermographism in 57.1%versus 4.4%, and melanosis in 46.9%versus 0%. In 38.7% of the PBC patients the dermatologic lesion was the presenting symptom. CONCLUSIONS: PBC patients present with a wide variety of cutaneous manifestations varying in severity. Multiple skin fungal infections have been found even in the early stages. Since in more than one third of our PBC patients the dermatologic lesion was the presenting sign or symptom leading to diagnosis we believe that physicians should be aware so that a prompt and early diagnosis may be achieved.
Meri Koulentaki; Despina Ioannidou; Maria Stefanidou; Sofia Maraki; I Drigiannakis; Philippas Dimoulios; Jean Marie Enele Melono; Androniki Tosca; Elias A Kouroumalis
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Publication Detail:
Type:  Journal Article     Date:  2006-02-08
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  101     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-04-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110 Heraklion, Crete, Greece.
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MeSH Terms
Aged, 80 and over
Diagnosis, Differential
Liver Cirrhosis, Biliary / complications,  diagnosis*
Middle Aged
Prospective Studies
Skin Diseases / diagnosis,  etiology*
Statistics as Topic
Comment In:
Am J Gastroenterol. 2007 Jan;102(1):210-1; author reply 211   [PMID:  17278271 ]

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