Document Detail


Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases.
MedLine Citation:
PMID:  15934071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe dermatologic manifestations of the antiphospholipid syndrome (APS) and to investigate possible correlations between livedo reticularis and other APS manifestations. METHODS: We conducted a single-center study of 200 consecutive patients with primary or systemic lupus erythematosus-related APS. To qualify for the study, patients had to fulfill clinical and laboratory criteria from the most recent international consensus statement on classification of definite APS. Dermatologic manifestations were systematically evaluated by a dermatologist. Only dermatologic lesions that may be related to APS were included in the analyses. Correlations between livedo reticularis and other APS manifestations were determined using Fisher's 2-tailed, chi-square, and nonparametric Mann-Whitney tests. RESULTS: Dermatologic manifestations were noted in 49% of the patients and were the presenting manifestations in 30.5%. Livedo reticularis was the most frequent manifestation, observed in 25.5% of the patients. Livedo reticularis was shown to be significantly associated with cerebral or ocular ischemic arterial events (odds ratio [OR] 10.8, 95% confidence interval [95% CI] 5.2-22.5), seizures (OR 6.5, 95% CI 2.6-16), all arterial events (OR 6, 95% CI 2.9-12.6), heart valve abnormalities detected on echocardiography (OR 7.3, 95% CI 3.6-14.7), and arterial systemic hypertension (>/=160/90 mm Hg) (OR 2.9, 95% CI 1.5-5.7). Conversely, it was observed with decreased frequency in patients with only venous thrombosis (OR 0.2, 95% CI 0.1-0.5). CONCLUSION: The dermatologic manifestations of APS are frequently the presenting feature of the syndrome, and livedo reticularis is significantly associated with the arterial subset of APS.
Authors:
Camille Francès; Suzanne Niang; Emmanuel Laffitte; Francois le Pelletier; Nathalie Costedoat; Jean Charles Piette
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  52     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-28     Completed Date:  2005-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1785-93     Citation Subset:  AIM; IM    
Affiliation:
Groupe Hospitalier Pitié-Salpêtrière, Paris, France. camille.frances@psl.ap-hop-paris.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antiphospholipid Syndrome / immunology*
Child
Female
Humans
Lupus Erythematosus, Systemic / complications,  immunology
Male
Middle Aged
Skin Diseases / immunology
Skin Diseases, Vascular / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial ...
Next Document:  Interleukin-4 can be a key positive regulator of inflammatory arthritis.