| Dermatologic emergencies. | |
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MedLine Citation:
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PMID: 20879700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Life-threatening dermatologic conditions include Rocky Mountain spotted fever; necrotizing fasciitis; toxic epidermal necrolysis; and Stevens-Johnson syndrome. Rocky Mountain spotted fever is the most common rickettsial disease in the United States, with an overall mortality rate of 5 to 10 percent. Classic symptoms include fever, headache, and rash in a patient with a history of tick bite or exposure. Doxycycline is the first-line treatment. Necrotizing fasciitis is a rapidly progressive infection of the deep fascia, with necrosis of the subcutaneous tissues. It usually occurs after surgery or trauma. Patients have erythema and pain out of proportion to the physical findings. Immediate surgical debridement and antibiotic therapy should be initiated. Stevens-Johnson syndrome and toxic epidermal necrolysis are acute hypersensitivity cutaneous reactions. Stevens-Johnson syndrome is characterized by target lesions with central dusky purpura or a central bulla. Toxic epidermal necrolysis is a more severe reaction with full-thickness epidermal necrosis and exfoliation. Most cases of Stevens-Johnson syndrome and toxic epidermal necrolysis are drug induced. The causative drug should be discontinued immediately, and the patient should be hospitalized for supportive care. |
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Authors:
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Richard P Usatine; Natasha Sandy |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American family physician Volume: 82 ISSN: 1532-0650 ISO Abbreviation: Am Fam Physician Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2010-11-15 Revised Date: 2011-04-07 |
Medline Journal Info:
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Nlm Unique ID: 1272646 Medline TA: Am Fam Physician Country: United States |
Other Details:
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Languages: eng Pagination: 773-80 Citation Subset: AIM; IM |
Affiliation:
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University of Texas Health Science Center, San Antonio, TX, USA. usatine@uthscsa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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adverse effects Emergencies Epidermal Necrolysis, Toxic / diagnosis*, etiology Fasciitis, Necrotizing / diagnosis* Female Humans Male Rocky Mountain Spotted Fever / diagnosis* Stevens-Johnson Syndrome / diagnosis*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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