Document Detail


Dermatan sulfate in the synovial fluid of patients with knee osteoarthritis.
MedLine Citation:
PMID:  17694263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biochemical factors play an important role in osteoarthritis (OA) pathogenesis. The purpose of this study is to clarify whether the dermatan sulfate (DS) levels in the synovial fluid of patients with knee OA are related to residual cartilage. Synovial fluid was obtained from 51 OA patients. Knee radiographs were evaluated with the Kellgren-Lawrence (K/L) grading scale. The levels of the following disaccharides were measured by high-performance liquid chromatography (HPLC): DS (DSDeltaDi4S), chondroitin 6-sulfate (CSDeltaDi6S), and chondroitin 4-sulfate (CSDeltaDi4S). The concentration of cartilage oligomeric matrix protein (COMP) was measured by a sandwich ELISA. The levels of DSDeltaDi4S in Grades 0 and I OA were significantly higher than levels in Grade II (P = 0.0458), Grade III (P < 0.0001) and Grade IV (P < 0.0001), and we found strong relationships between the levels of DSDeltaDi4S and those of CSDeltaDi6S (P < 0.0001, r = 0.705), CSDeltaDi4S (P < 0.0001, r = 0.750), and COMP (P < 0.0001, r = 0.699). We conclude that the presence of DSDeltaDi4S reflects proteoglycan metabolism in the residual articular cartilage of OA patients. This suggests that metabolism of the small leucine-rich repeat proteoglycans decorin and biglycan, which contain chains of DSDeltaDi4S, is similar to that of aggrecan.
Authors:
Shigeki Momohara; Naoyuki Okada; Katsunori Ikari; Shoji Mizuno; Hiroshi Okamoto
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Publication Detail:
Type:  Journal Article     Date:  2007-08-20
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  17     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Affiliation:
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada, Shinjuku-ku, Tokyo, 162-0054, Japan. smomohara@ior.twmu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aggrecans / metabolism*
Biological Markers
Cartilage / metabolism*,  pathology
Chondroitin Sulfates / analysis*
Dermatan Sulfate / analysis*
Extracellular Matrix Proteins / analysis,  metabolism
Female
Glycoproteins / analysis
Humans
Male
Middle Aged
Osteoarthritis, Knee / physiopathology*
Proteoglycans / metabolism
Synovial Fluid / chemistry*
Chemical
Reg. No./Substance:
0/Aggrecans; 0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/Proteoglycans; 0/cartilage matrix protein; 0/decorin; 123939-84-4/biglycan; 24967-94-0/Dermatan Sulfate; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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