Document Detail

Dermal mucinosis as a sign of venous insufficiency.
MedLine Citation:
PMID:  19614999     Owner:  NLM     Status:  MEDLINE    
Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans. We describe two cases of dermal mucinosis in the setting of chronic venous insufficiency. Both patients presented with painful, edematous lower extremity plaques. Biopsies of all lesions showed striking dermal mucin deposition, a slight increase in small blood vessel density, slightly thickened vessel walls and no inflammation. Neither patient showed laboratory or clinical findings consistent with a secondary mucinosis such as thyroid dysfunction, lupus erythematosus, dermatomyositis, scleroderma, granuloma annulare, graft-vs.-host disease or mucin deposition post-ultraviolet or photochemotherapy treatment. Both patients were diagnosed with localized cutaneous mucinosis secondary to venous insufficiency. The clinicopathological features of this entity are described, and a pathogenic mechanism is proposed.
Rupa Pugashetti; Daniel C Zedek; Elizabeth V Seiverling; Priya Rajendran; Timothy Berger
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-10
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-03-31     Revised Date:  2010-07-30    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  292-6     Citation Subset:  IM    
Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA.
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MeSH Terms
Leg / pathology*
Middle Aged
Mucinoses / complications,  pathology*
Skin / pathology*
Thigh / pathology*
Venous Insufficiency / complications,  pathology*
Comment In:
J Cutan Pathol. 2010 Sep;37(9):1024; author reply 1025   [PMID:  20236373 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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