Document Detail


Dermal mass aspirate from a Persian cat.
MedLine Citation:
PMID:  14655108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 1-year-old spayed female Persian cat with alopecia and weight loss had numerous variably ulcerated dermal nodules. Cytologic examination of an aspirate of one of the nodules revealed pyogranulomatous inflammation along with septate hyphae and basophilic round bodies, 0.5-1.0 microm in diameter, surrounded by a thin clear halo (arthrospores). The cytologic diagnosis was dermatophytic pseudomycetoma. Histologically, there were dermal granulomas containing poorly staining, septate hyphae with bulbous spores embedded within abundant amorphous eosinophilic material (Splendore-Hoeppli reaction), and the histologic diagnosis was pseudomycetoma-associated chronic multifocal severe granulomatous dermatitis with lymphocytic perifolliculitis and furunculosis. Microsporum canis was cultured from the lesion. Pseudomycetomas are distinguished from fungal mycetomas, or eumycotic mycetomas, by the findings of multiple lesions, lack of a history of skin trauma, an association with dermatophytes, most commonly Microsporum canis, and, histologically, lack of true cement material and a more abundant Splendore-Hoeppli reaction in pseudomycetomas. Additionally, pseudomycetomas differ from dermatophytosis, in which lesions are restricted to epidermal structures. Persian cats have a high incidence of pseudomycetoma formation, suggesting a heritable predisposition. The prognosis is fair with systemic antifungal therapy. When examining cytologic specimens from Persian cats with single or multiple dermal nodules, especially if pyogranulomatous inflammation is present, a diagnosis of pseudomycetoma should be suspected and is warranted if arthrospores and refractile septate hyphae are present.
Authors:
Kurt Zimmerman; Bernard Feldman; John Robertson; Erin S Herring; Thomas Manning
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary clinical pathology / American Society for Veterinary Clinical Pathology     Volume:  32     ISSN:  0275-6382     ISO Abbreviation:  Vet Clin Pathol     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9880575     Medline TA:  Vet Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. kzimmerm@vt.edu
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MeSH Terms
Descriptor/Qualifier:
Alopecia / etiology,  veterinary
Animals
Antifungal Agents / therapeutic use
Cat Diseases / drug therapy,  microbiology,  pathology*
Cats
Dermatomycoses / drug therapy,  microbiology,  pathology,  veterinary*
Female
Microsporum / isolation & purification*
Prognosis
Weight Loss
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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