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Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb: effect of nonylphenolethoxylate and protective gloves.
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MedLine Citation:
PMID:  11266321     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dermal exposure has become the major route of human occupational exposure to pesticides. Detergents are used as part of formulated pesticide products and are known to change the barrier properties of human skin in vitro. However, studies on the influence of detergents as well as protective glove materials on dermal penetration of pesticides are scarce. In an experiment using in vitro static diffusion cells mounted with human skin, we evaluated the effect of nonylphenol-ethoxylate on dermal penetration of three extensively used pesticides--methiocarb, paclobutrazol, and pirimicarb--and the protection against dermal penetration offered by protective gloves made of latex or nitrile. There was a general tendency, though not statistically significant for all pesticides, for nonylphenolethoxylate to decrease the percutaneous penetration of the three pesticides. The nitrile generally offered better protection against percutaneous penetration of pesticides than did latex, but the degree of protection decreased over time and depended on the pesticides used.
Authors:
J B Nielsen; H R Andersen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  109     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-05-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Affiliation:
The Institute of Public Health, University of Southern Denmark, Odense, Denmark. jbnielsen@health.sdu.dk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cadaver
Carbamates / pharmacokinetics*
Denmark
Detergents*
Ethylene Glycols*
Female
Gloves, Protective*
Humans
Methiocarb / pharmacokinetics*
Middle Aged
Occupational Exposure
Pesticides / pharmacokinetics*
Pyrimidines*
Skin Absorption*
Triazoles / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Carbamates; 0/Detergents; 0/Ethylene Glycols; 0/Pesticides; 0/Pyrimidines; 0/Triazoles; 2032-65-7/Methiocarb; 23103-98-2/pirimicarb; 27986-36-3/terics; 76738-62-0/paclobutrazol
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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 2 Year: 2001
Volume: 109 Issue: 2
First Page: 129 Last Page: 132
ID: 1240631
PubMed Id: 11266321
Publisher Item Identifier: sc271_5_1835

Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb: effect of nonylphenolethoxylate and protective gloves.
J B Nielsen
H R Andersen
The Institute of Public Health, University of Southern Denmark, Odense, Denmark. jbnielsen@health.sdu.dk


Article Categories:
  • Research Article


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