| Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb: effect of nonylphenolethoxylate and protective gloves. | |
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MedLine Citation:
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PMID: 11266321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dermal exposure has become the major route of human occupational exposure to pesticides. Detergents are used as part of formulated pesticide products and are known to change the barrier properties of human skin in vitro. However, studies on the influence of detergents as well as protective glove materials on dermal penetration of pesticides are scarce. In an experiment using in vitro static diffusion cells mounted with human skin, we evaluated the effect of nonylphenol-ethoxylate on dermal penetration of three extensively used pesticides--methiocarb, paclobutrazol, and pirimicarb--and the protection against dermal penetration offered by protective gloves made of latex or nitrile. There was a general tendency, though not statistically significant for all pesticides, for nonylphenolethoxylate to decrease the percutaneous penetration of the three pesticides. The nitrile generally offered better protection against percutaneous penetration of pesticides than did latex, but the degree of protection decreased over time and depended on the pesticides used. |
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Authors:
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J B Nielsen; H R Andersen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental health perspectives Volume: 109 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-27 Completed Date: 2001-05-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: United States |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: IM |
Affiliation:
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The Institute of Public Health, University of Southern Denmark, Odense, Denmark. jbnielsen@health.sdu.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cadaver Carbamates / pharmacokinetics* Denmark Detergents* Ethylene Glycols* Female Gloves, Protective* Humans Methiocarb / pharmacokinetics* Middle Aged Occupational Exposure Pesticides / pharmacokinetics* Pyrimidines* Skin Absorption* Triazoles / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Carbamates; 0/Detergents; 0/Ethylene Glycols; 0/Pesticides; 0/Pyrimidines; 0/Triazoles; 2032-65-7/Methiocarb; 23103-98-2/pirimicarb; 27986-36-3/terics; 76738-62-0/paclobutrazol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 2 Year: 2001 Volume: 109 Issue: 2 First Page: 129 Last Page: 132 ID: 1240631 PubMed Id: 11266321 Publisher Item Identifier: sc271_5_1835 |
| Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb: effect of nonylphenolethoxylate and protective gloves. | |
| J B Nielsen | |
| H R Andersen | |
| The Institute of Public Health, University of Southern Denmark, Odense, Denmark. jbnielsen@health.sdu.dk |
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