Document Detail

Dermal extracellular matrix in cutaneous leprosy lesions.
MedLine Citation:
PMID:  10407626     Owner:  NLM     Status:  MEDLINE    
Thirty-eight biopsies of cutaneous lesions from leprosy patients [borderline tuberculoid (BT) 14, borderline lepromatous (BL) 18, lepromatous (LL) 6] were processed for staining of some extracellular matrix (ECM) components (collagen, proteoglycans, elastic fibers and fibronectin). Specific histological staining and the indirect immunofluorescence method with antibodies to collagen and fibronectin were utilized. The ECM of the normal dermis was strikingly modified in the inflammatory infiltrate. By Gomori's reticulin and anti-fibronectin immunostaining, replacement of the dense interlaced collagen fibers with a reticular mesh was observed in the infiltrate. The immunoreactivity obtained with anti-type I and anti-type III collagens showed positive fibrils and a lumpy pattern in the lepromatous and tuberculoid lesions with a higher amount in the lepromatous lesions. The lack of clear-cut boundaries between the normal dermis and the inflammatory infiltrate in the lepromatous (BL, LL) lesions was correlated with the blurred limits of the clinical lesions of this pole of the leprosy spectrum. Absence of elastic fibers in the infiltrate was a constant finding, and fuchsin-positive microfibrils were found in some infiltrates. The clear zone of lepromatous lesions was devoid of oxytalan fibers. Elaunin fiber rings around sweat gland acini were present even when the leprosy infiltrate was seen enveloping them. The original ECM is replaced by a newly assembled one, which is suited for the dynamic nature of the inflammatory process. The trophic effects of the ECM upon the cutaneous epithelial structures are modified so that atrophy and late degeneration ensues. These ECM modifications contribute, therefore, to the biological alterations of the skin functions in leprosy.
S L Antunes; M E Gallo; S M de Almeida; E Mota; M Pelajo; H L Lenzl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  67     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-35     Citation Subset:  IM    
Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
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MeSH Terms
Collagen / immunology
Extracellular Matrix / immunology,  pathology*
Extracellular Matrix Proteins / immunology*
Fibronectins / immunology
Fluorescent Antibody Technique, Indirect
Leprosy, Lepromatous / pathology*
Microscopy, Confocal
Mycobacterium leprae / isolation & purification
Proteoglycans / immunology
Skin / pathology
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Fibronectins; 0/Proteoglycans; 9007-34-5/Collagen

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