| Dermal arteritis of the nasal philtrum in a Giant Schnauzer and three Saint Bernard dogs. | |
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MedLine Citation:
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PMID: 12358612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arteritis of the nasal philtrum is described in four dogs. Two of the Saint Bernards were related. The lesions were solitary, well-circumscribed, linear ulcers that were neither pruritic nor painful. The age of the dogs at the time the owners first noticed the lesion ranged from 3 to 6 years. The ulcers had been present for 0.5-5 years before diagnosis was pursued. Three of the dogs experienced repeated, mild episodes of arterial bleeding from the ulcers. Two dogs also experienced a severe episode of bleeding that required surgical intervention. Histopathological findings included a V-shaped ulcer, neutrophilic dermal inflammation subjacent to the ulcer and lymphoplasmacytic dermatitis bordering the ulcer. The most remarkable pathological findings were present in the deep dermal arteries and arterioles subjacent to the ulcer. The changes were characterized by subendothelial spindle cell proliferation with marked extracellular matrix deposition that stained blue with Alcian Blue (mucin) and Masson's trichrome (collagen) and resulted in intimal thickening, and stenosis of dermal arteries and arterioles. Immunohistochemical studies suggested that the proliferating spindle cells were of either myofibroblast or smooth muscle origin (actin and vimentin positive). Anti-inflammatory therapy (glucocorticoids; tetracycline and niacinamide; fish oil) may be beneficial for long-term control of this condition, however, long-term maintenance treatment appears to be necessary. |
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Authors:
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Sheila M F Torres; Timothy O Brien; Danny W Scott |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Veterinary dermatology Volume: 13 ISSN: 0959-4493 ISO Abbreviation: Vet. Dermatol. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-02 Completed Date: 2002-12-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9426187 Medline TA: Vet Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 275-81 Citation Subset: IM |
Affiliation:
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Department of Small Animal Clinical Sciences, Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul 55108, USA. torre009@tc.umn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / therapeutic use Arteritis / diagnosis, veterinary* Breeding Diagnosis, Differential Dog Diseases / diagnosis*, drug therapy, pathology Dogs Female Male Nose Skin Diseases / diagnosis, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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