Document Detail


Derivatives of gallic acid induce apoptosis in tumoral cell lines and inhibit lymphocyte proliferation.
MedLine Citation:
PMID:  9466819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of gallic acid (3,4,5-trihydroxybenzoic acid) and its alkyl esters (methyl, propyl, octyl, and lauryl) has been studied on several tumoral and nontumoral cells. Three types of behavior have been observed; the first type is represented by the mouse B cell lymphoma Wehi 231 cell line in which death occurs according to the biochemical characteristics of classical apoptosis showing the DNA ladder fragmentation pattern. The second type is represented by the mouse fibroblast L929 cell line in which morphological characteristics such as cell shrinkage, chromatin condensation, and appearance of apoptotic bodies can be evidenced by microscopical observation. However, the typical DNA fragmentation is absent. Peripheral blood lymphocytes are representative of a third type of behavior. In a resting state they can withstand higher concentrations of these compounds. If the drug is washed, they proliferate normally upon the addition of the mitogen phytohemagglutinin (PHA). However, if the drug is added in the presence of PHA, a clear antiproliferative effect can be demonstrated. A special interest for these compounds stems from the fact that some of them are currently used as antioxidant food additives with the European Community codes E-310 (propylgallate), E-311 (octylgallate), and E-312 (laurylgallate).
Authors:
A Serrano; C Palacios; G Roy; C Cespón; M L Villar; M Nocito; P González-Porqué
Related Documents :
19709579 - Supercritical carbon dioxide extract of physalis peruviana induced cell cycle arrest an...
10082299 - Analysis of apoptosis by laser scanning cytometry.
12115619 - Inhibition of caspase or fadd function blocks proliferation but not map kinase-activati...
20397199 - Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.
12975549 - The molecular mechanism of arsenic trioxide-induced apoptosis and oncosis in leukemia/l...
11918309 - Nitric oxide induces osteoblast apoptosis through the de novo synthesis of bax protein.
8006519 - Regulation of the threshold for lipoprotein-induced acyl-coa:cholesterol o-acyltransfer...
19687139 - Dynamic chromosome organization and protein localization coordinate the regulatory circ...
18431399 - Mechanisms of asymmetric cell division: flies and worms pave the way.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  350     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Affiliation:
Department of Immunology, Hospital Ramón y Cajal, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / toxicity*
Apoptosis*
B-Lymphocytes / drug effects
Dose-Response Relationship, Drug
Fibroblasts / drug effects
Food Preservatives / toxicity*
Gallic Acid / analogs & derivatives*,  toxicity
Humans
Lymphocyte Activation / drug effects*
Lymphoma, B-Cell
Mice
Propyl Gallate / toxicity
Toxicity Tests
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Food Preservatives; 1034-01-1/octyl gallate; 1166-52-5/lauryl gallate; 121-79-9/Propyl Gallate; 149-91-7/Gallic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Induction of the human CYP1A2 enhancer by phorbol ester.
Next Document:  N-acetyl-L-glutamate and the urea cycle in gulf toadfish (Opsanus beta) and other fish.