Document Detail

Derivatives of 2-mercaptobenzenesulphonamide. XX. Synthesis and cardiovascular effects of some 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methylbenzenesulphonylimino]- perhydropyrimidines.
MedLine Citation:
PMID:  9415219     Owner:  NLM     Status:  MEDLINE    
A series of 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methyl- benzenesulphonylimino]perhydropyrimidines [IV-X] and their hydrochlorides [IVa-VIIIa] were prepared. The antiarrhythmic effect of the most active compound [Va] was comparable to the reference drugs, quinidine and procainamide. The influence of the tested compounds [IVa, Va, VIa] on the blood pressure and heart rate of rats as well as the acute toxicity in mice were studied.
E Pomarnacka; K Oledzka
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  53     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1998-01-30     Completed Date:  1998-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  443-7     Citation Subset:  IM    
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced,  prevention & control
Cardiovascular Agents / chemical synthesis*
Lethal Dose 50
Sulfhydryl Compounds / chemical synthesis*,  pharmacology,  toxicity
Sulfonamides / chemical synthesis*,  pharmacology,  toxicity
Reg. No./Substance:
0/Cardiovascular Agents; 0/Sulfhydryl Compounds; 0/Sulfonamides

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