Document Detail


Derivation of a target concentration of Pb in soil based on elevation of adult blood pressure.
MedLine Citation:
PMID:  8638039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increase in systolic blood pressure in males appears to be the most sensitive adult endpoint appropriate for deriving a health risk-based target level of lead (Pb) in soil. Because the response of blood pressure to blood Pb concentration (PbB) has no apparent threshold, traditional approaches based on the application of a Reference Dose (RfD) are not applicable. An alternative approach is presented based on a model which predicts the population shift in systolic blood pressure from ingestion of Pb contaminated soil as a simultaneous function of exposure to Pb in soil, the baseline distribution of blood Pb concentration in the population and baseline distribution of systolic pressure in the population. This model is analyzed using Monte Carlo analysis to predict the population distribution of systolic pressure resulting from Pb exposure. Based on this analysis, it is predicted that for adult males 18-65 years old, exposure to 1000 ppm Pb in soil will result in an increase of approximately 1 mm Hg systolic pressure, an increase in the incidence of systolic hypertension (i.e., systolic pressure > 140 mm Hg) of approximately 1% and an increase in PbB of 1-3 micrograms/dl. Based on the proposition that these adverse effects can be considered de minimis, 1000 ppm Pb in soil is proposed as a target soil concentration for adult exposure. Available data do not appear to be adequate to predict the newborn PbB level which would result from exposure to this soil level during pregnancy.
Authors:
A H Stern
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Risk analysis : an official publication of the Society for Risk Analysis     Volume:  16     ISSN:  0272-4332     ISO Abbreviation:  Risk Anal.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-07-11     Completed Date:  1996-07-11     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  8109978     Medline TA:  Risk Anal     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-10     Citation Subset:  IM    
Affiliation:
Division of Science and Research, New Jersey Department of Environmental Protection, Trenton 08625, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Pressure / drug effects*
Female
Humans
Infant, Newborn
Lead / administration & dosage,  blood,  toxicity*
Male
Maximum Allowable Concentration
Middle Aged
Models, Biological
Monte Carlo Method
Pregnancy
Risk
Soil Pollutants / administration & dosage,  blood,  toxicity*
Systole / drug effects
Chemical
Reg. No./Substance:
0/Soil Pollutants; 7439-92-1/Lead
Comments/Corrections
Erratum In:
Risk Anal 1996 Oct;16(5):725

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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