Document Detail

Derivation of severity index for rheumatoid arthritis and its association with healthcare outcomes.
MedLine Citation:
PMID:  22533525     Owner:  NLM     Status:  Publisher    
Abstract Objectives: Develop a claims-based severity index for rheumatoid arthritis (RA) using the Veterans Health Administration (VHA) database. Methods: Adult patients with at least two RA diagnoses 2 months apart were identified between 10/1/2008-09/30/2009. Patients were required to have at least 12 months continuous health plan enrollment before and after the index date (first RA diagnosis date) for an overall study period of 10/1/2007-09/30/2010. A severity index for rheumatoid arthritis (SIFRA was developed by calculating a weighted sum of 34 RA-related indicators assessed by an expert Delphi panel of six rheumatologists, including laboratory, clinical and functional status, extra-articular manifestations, surgical history, and medications, during a 1-year pre-index period. Separate SIFRA versions were derived for patients with and without laboratory information. Correlations between SIFRA and previously validated claims-based indexes for RA severity (CIRAS), and other traditional comorbidity indexes were calculated during the pre-index period. The relationship between SIFRA and follow-up healthcare costs was also examined using histograms. Results: The Spearman's rank correlations between SIFRA and CIRAS were 0.525 for SIFRA without and 0.539 with laboratory data. The correlations between SIFRA and the Charlson Comorbidity Index (CCI) (0.1503 without, 0.1135 with laboratory data), Elixhauser Index (ELIX) (0.105 without, 0.079 with laboratory data) and Chronic Disease Score (CDS) (0.255 without, 0.239 with laboratory data) were low. Histograms showed that patients in the upper tercile of SIFRA incurred $9,123 more all-cause and $1,326 more RA-related healthcare costs during the 1-year post-index period than patients in the lower tercile. Using SIFRA in combination with CCI, CDS or ELIX significantly increased the percentage of variation explained in outcomes measures. Limitations: Patients in the VHA database may not represent typical RA patients since the database generally contains older, economically disadvantaged men with a high disease burden. Validity of the score is indirectly based on disease activity score 28 (DAS28), which measures disease activity rather than severity. Conclusions: SIFRA was found to have moderate correlations with the previously validated CIRAS score, and demonstrated evidence of being a significant determinant of total and RA-related healthcare costs for RA patients. This study suggests that SIFRA could be an important methodological tool to control for severity in RA-related outcomes research.
O Baser; J Du; L Xie; H Wang; Ah Dysinger; L Wang
Related Documents :
17722705 - Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly ...
19203545 - Clinicopathological features and prognosis in immunoglobulin light and heavy chain depo...
22533525 - Derivation of severity index for rheumatoid arthritis and its association with healthca...
21432575 - Borderline typical symptoms in adult patients with attention deficit/hyperactivity diso...
10819385 - Physiological variables during open chest cardiopulmonary resuscitation: results from a...
6814135 - Effects of a dopamine antagonist (metoclopramide) on the release of the adenohypophysea...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-26
Journal Detail:
Title:  Journal of medical economics     Volume:  -     ISSN:  1941-837X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9892255     Medline TA:  J Med Econ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Burden of Immune Thrombocytopenia in Adults: Evaluation of the Thrombopoietin Receptor Agonist R...
Next Document:  Economic outcomes of exenatide vs liraglutide in type 2 diabetes patients in the United States: resu...