Document Detail

Derivation of the distensibility coefficient using tissue Doppler as a marker of arterial function.
MedLine Citation:
PMID:  17919124     Owner:  NLM     Status:  MEDLINE    
To date, the main cardiovascular application of TDI (tissue Doppler imaging) has been in myocardial evaluation. In the present study, we investigated the feasibility and reproducibility of assessing arterial elasticity using the DC (distensibility coefficient) measured by TDI, the correlation of this with the DC obtained by other methods and the DC in patients with various degrees of cardiovascular risk. We studied 450 subjects (256 men; age, 51+/-10 years) with and without risk factors of cardiovascular disease. Arterial displacement was measured from TDI, and B-mode and M-mode images of the common carotid artery in the longitudinal plane, and the DC with each method was compared. Linear regression showed a good correlation between all three methods. The results for TDI and B-mode were comparable [(21+/-10) compared with (21+/-10)x10(-3)/kPa respectively; P=not significant], but there were significant differences between TDI and M-mode [(21+/-10) compared with (31+/-13)x10(-3)/kPa respectively; P<0.0001] and between B-mode and M-mode [(21+/-10) compared with (31+/-13)x10(-3)/kPa respectively; P<0.0001]. Similarly, Bland-Altman analysis showed the least variability in the DC between TDI and B-mode, and there were no significant differences between the average measurements. The TDI DC also had the lowest paired difference for inter-observer variability [(-0.1+/-1.1)x10(-3)/kPa; P=not significant]. In conclusion, the results of the present study suggest that TDI of the carotid arteries is feasible, comparable with B-mode measurements, more robust than M-mode and less variable than the other methods.
Brian A Haluska; Leanne Jeffriess; Joseph Brown; Melodie Downey; Stephane G Carlier; Thomas H Marwick
Related Documents :
7997104 - Acute change of exercised muscle using magnetization transfer contrast mr imaging.
9183604 - Treadmill exercise echocardiography: methodology and clinical role.
2661584 - The effect of nimodipine on the evolution of human cerebral infarction studied by pet.
2563954 - Effect of antianginal medications on the prognostic value of exercise thallium scintigr...
16038634 - Protective effects of l-arginine on pulmonary oxidative stress and antioxidant defenses...
20020784 - Combining hypoxic methods for peak performance.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  114     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  IM    
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD 4102, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiovascular Diseases / etiology,  physiopathology*
Carotid Artery, Common / physiopathology*,  ultrasonography*
Epidemiologic Methods
Middle Aged
Observer Variation
Ultrasonography, Doppler / methods
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ...
Next Document:  The role of the neurobiologist in redefining the diagnosis of autism.