| Deregulation of cell cycle machinery in pancreatic cancer. | |
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MedLine Citation:
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PMID: 17703085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disrupted cell cycle machinery is commonly thought to result in loss of proliferative control. Standard therapies target these rapidly dividing cells, yet they are ineffective against pancreatic cancer, suggesting that its development and/or progression might deviate from standard paradigms. Supposedly essential cell cycle components are actually dispensable in mice, and accumulating evidence indicates that they play more diverse roles during apoptosis, signal transduction, and cell migration. A better understanding of how pancreatic cancer cells proliferate and the contribution of disrupted cell cycle machinery would provide much needed opportunities for developing new diagnostic and therapeutic options to improve patient outcome. |
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Authors:
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Lucas P Nacusi; Robert J Sheaff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 7 ISSN: 1424-3911 ISO Abbreviation: Pancreatology Publication Date: 2007 |
Date Detail:
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Created Date: 2007-09-27 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 373-7 Citation Subset: IM |
Copyright Information:
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2007 S. Karger AG, Basel and IAP |
Affiliation:
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Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minn., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology Cell Cycle / physiology* Cell Proliferation Humans Mice Pancreas / cytology* Pancreatic Neoplasms / drug therapy, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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