Document Detail

Deregulated c-fos augments cell proliferation of B cells mediated by lipopolysaccharide.
MedLine Citation:
PMID:  8443797     Owner:  NLM     Status:  MEDLINE    
We have examined effects of the deregulated c-fos protein on the lipopolysaccharide (LPS)-mediated B cell responses using splenic B cells from transgenic lines carrying the mouse c-fos gene under the control of the H-2K (H2-c-fos) and the inducible Mx promoter (Mx-c-fosD). High c-fos expression was induced in Mx-c-fosD B cells by LPS stimulation. DNA synthesis of the B cells from both lines was augmented depending on the amount of exogenous c-fos. This augmentation resulted in the increase of IgM and IgG2b productions in the culture. These results suggest a functional role of c-fos protein in cell cycle progression of the activated B cells.
M Takada; T Koizumi; D Bachiller; U Rüther; T Tokuhisa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  68     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Department of Immunology, ICMR, Kobe University School of Medicine, Hyogo, Japan.
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MeSH Terms
B-Lymphocytes / immunology*
DNA / biosynthesis
Gene Expression Regulation*
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Lipopolysaccharides / pharmacology
Lymphocyte Activation*
Mice, Transgenic
Proto-Oncogene Proteins c-fos*
Spleen / cytology
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 0/Lipopolysaccharides; 0/Proto-Oncogene Proteins c-fos; 9007-49-2/DNA

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