Document Detail

Derecruitment test and surfactant therapy in patients with acute lung injury.
MedLine Citation:
PMID:  22928094     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Introduction. A recruitment maneuver (RM) may improve gas exchange in acute lung injury (ALI). The aim of our study was to assess the predictive value of a derecruitment test in relation to RM and to evaluate the efficacy of RM combined with surfactant instillation in patients with ALI. Materials and Methods. Thirteen adult mechanically ventilated patients with ALI were enrolled into a prospective pilot study. The patients received protective ventilation and underwent RM followed by a derecruitment test. After a repeat RM, bovine surfactant (surfactant group, n = 6) or vehicle only (conventional therapy group, n = 7) was instilled endobronchially. We registered respiratory and hemodynamic parameters, including extravascular lung water index (EVLWI). Results. The derecruitment test decreased the oxygenation in 62% of the patients. We found no significant correlation between the responses to the RM and to the derecruitment tests. The baseline EVLWI correlated with changes in SpO(2) following the derecruitment test. The surfactant did not affect gas exchange and lung mechanics but increased EVLWI at 24 and 32 hrs. Conclusions. Our study demonstrated no predictive value of the derecruitment test regarding the effects of RM. Surfactant instillation was not superior to conventional therapy and might even promote pulmonary edema in ALI.
Alexey A Smetkin; Vsevolod V Kuzkov; Konstantin M Gaidukov; Lars J Bjertnaes; Mikhail Y Kirov
Related Documents :
17579524 - Recommendations for detection and management of unsuitable samples in clinical laborato...
24169024 - Single-item or two-item literacy screener to predict the s-tofhla among adult hemodialy...
9702944 - Evaluating stat testing options in an academic health center: therapeutic turnaround ti...
25354444 - Universal screening test based on analysis of circulating organ-enriched micrornas: a n...
10696854 - Nasal provocation test in the diagnosis of natural rubber latex allergy.
8264364 - Study into the ability of healthy people of small stature to satisfy the sampling requi...
Publication Detail:
Type:  Journal Article     Date:  2012-08-15
Journal Detail:
Title:  Critical care research and practice     Volume:  2012     ISSN:  2090-1313     ISO Abbreviation:  Crit Care Res Pract     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-08-30     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101539357     Medline TA:  Crit Care Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  428798     Citation Subset:  -    
Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Troitsky Avenue 51, Arkhangelsk 163000, Russia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physical activity targeted at maximal lipid oxidation: a meta-analysis.
Next Document:  Does Personality Predict Depression and Use of an Internet-Based Intervention for Depression among A...