| Derangements of post-ischemic cerebral blood flow by protein kinase C delta. | |
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MedLine Citation:
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PMID: 20813167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral ischemia causes blood flow derangements characterized by hyperemia (increased cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF). We previously demonstrated that protein kinase C delta (δPKC) plays an important role in hippocampal neuronal death after ischemia. However, whether part of this protection is due to the role of δPKC on CBF following cerebral ischemia remains poorly understood. We hypothesized that δPKC exacerbates hyperemia and subsequent hypoperfusion resulting in CBF derangements following ischemia. Sprague-Dawley (SD) rats pretreated with a δPKC specific inhibitor (δV1-1, 0.5 mg/kg) exhibited attenuation of hyperemia and latent hypoperfusion characterized by vasoconstriction followed by vasodilation of microvessels after 2-vessel occlusion plus hypotension measured by 2-photon microscopy. In an asphyxial cardiac arrest model (ACA), SD rats treated with δV1-1 (pre- and post-ischemia) exhibited improved perfusion after 24 h and less hippocampal CA1 neuronal death 7 days after ACA. These results suggest possible therapeutic potential of δPKC in modulating CBF and neuronal damage after cerebral ischemia. |
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Authors:
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H W Lin; R A Defazio; D Della-Morte; J W Thompson; S V Narayanan; A P Raval; I Saul; K R Dave; M A Perez-Pinzon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-09 |
Journal Detail:
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Title: Neuroscience Volume: 171 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-02-17 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 566-76 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 IBRO. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asphyxia / complications Brain / blood supply, metabolism, pathology Brain Ischemia / pathology, physiopathology* Cell Survival / drug effects Cerebrovascular Circulation* Heart Arrest / etiology, physiopathology Hyperemia / prevention & control Male Microcirculation Neurons / drug effects, pathology Protein Kinase C-delta / antagonists & inhibitors, physiology* Protein Transport Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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NS054147-01/NS/NINDS NIH HHS; NS34773/NS/NINDS NIH HHS; NS45676-01/NS/NINDS NIH HHS; R01 NS034773-12/NS/NINDS NIH HHS; R01 NS045676-06/NS/NINDS NIH HHS; R01 NS054147-04/NS/NINDS NIH HHS; T32-NS007459-10/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.13/Protein Kinase C-delta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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