Document Detail


Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression.
MedLine Citation:
PMID:  11425068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Compression tests have often been performed to assess the biomechanical properties of full-thickness articular cartilage. We tested whether the apparent homogeneous strain-dependent properties, deduced from such tests, reflect both strain- and depth-dependent material properties. Full-thickness bovine articular cartilage was tested by oscillatory confined compression superimposed on a static offset up to 45%. and the data fit to estimate modulus, permeability, and electrokinetic coefficient assuming homogeneity. Additional tests on partial-thickness cartilage were then performed to assess depth- and strain-dependent properties in an inhomogeneous model, assuming three discrete layers (i = 1 starting from the articular surface, to i = 3 up to the subchondral bone). Estimates of the zero-strain equilibrium confined compression modulus (H(A0)), the zero-strain permeability (kp0) and deformation dependence constant (M), and the deformation-dependent electrokinetic coefficient (ke) differed among individual layers of cartilage and full-thickness cartilage. HiA0 increased from layer 1 to 3 (0.27 to 0.71 MPa), and bracketed the apparent homogeneous value (0.47 MPa). ki(p0) decreased from layer 1 to 3 (4.6 x 10(-15) to 0.50 x 10(-15) m2/Pa s) and was less than the homogeneous value (7.3 x 10(-15) m2/Pa s), while Mi increased from layer 1 to 3 (5.5 to 7.4) and became similar to the homogeneous value (8.4). The amplitude of ki(e) increased markedly with compressive strain, as did the homogeneous value: at low strain, it was lowest near the articular surface and increased to a peak in the middle-deep region. These results help to interpret the biomechanical assessment of full-thickness articular cartilage.
Authors:
A C Chen; W C Bae; R M Schinagl; R L Sah
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomechanics     Volume:  34     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-06-26     Completed Date:  2001-07-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, Institute for Biomedical Engineering, University of California-San Diego, La Jolla 92093-0412, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Cartilage, Articular / physiology*
Cattle
Compressive Strength
Electrophysiology
Kinetics
Models, Biological
Permeability
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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