Document Detail


Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography.
MedLine Citation:
PMID:  20436605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrate the depth-resolved and detailed ocular perfusion maps within retina and choroid can be obtained from an ultrahigh sensitive optical microangiography (OMAG). As opposed to the conventional OMAG, we apply the OMAG algorithm along the slow scanning axis to achieve the ultrahigh sensitive imaging to the slow flows within capillaries. We use an 840 nm system operating at an imaging rate of 400 frames/s that requires 3 s to complete one 3D scan of approximately 3 x 3 mm(2) area on retina. We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology.
Authors:
Ruikang K Wang; Lin An; Peter Francis; David J Wilson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics letters     Volume:  35     ISSN:  1539-4794     ISO Abbreviation:  Opt Lett     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-07-20     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1467-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Capillaries / physiology*
Choroid / blood supply*
Equipment Design
Humans
Microcirculation
Regional Blood Flow
Retinal Vessels / physiology*
Sensitivity and Specificity
Tomography, Optical Coherence / instrumentation,  methods*
Grant Support
ID/Acronym/Agency:
R01 DC010201-01/DC/NIDCD NIH HHS; R01 DC010201-04/DC/NIDCD NIH HHS; R01 EB009682/EB/NIBIB NIH HHS; R01 EB009682-01/EB/NIBIB NIH HHS; R01 HL093140/HL/NHLBI NIH HHS; R01 HL093140-01/HL/NHLBI NIH HHS; R01 HL093140-01S1/HL/NHLBI NIH HHS; R01 HL093140-02/HL/NHLBI NIH HHS; R01 HL093140-05/HL/NHLBI NIH HHS; R01DC010201/DC/NIDCD NIH HHS; R01EB009682/EB/NIBIB NIH HHS; R01HL093140/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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