| Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. | |
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MedLine Citation:
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PMID: 20436605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrate the depth-resolved and detailed ocular perfusion maps within retina and choroid can be obtained from an ultrahigh sensitive optical microangiography (OMAG). As opposed to the conventional OMAG, we apply the OMAG algorithm along the slow scanning axis to achieve the ultrahigh sensitive imaging to the slow flows within capillaries. We use an 840 nm system operating at an imaging rate of 400 frames/s that requires 3 s to complete one 3D scan of approximately 3 x 3 mm(2) area on retina. We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology. |
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Authors:
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Ruikang K Wang; Lin An; Peter Francis; David J Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Optics letters Volume: 35 ISSN: 1539-4794 ISO Abbreviation: Opt Lett Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-20 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1467-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon 97237, USA. wangr@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Capillaries / physiology* Choroid / blood supply* Equipment Design Humans Microcirculation Regional Blood Flow Retinal Vessels / physiology* Sensitivity and Specificity Tomography, Optical Coherence / instrumentation, methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC010201-01/DC/NIDCD NIH HHS; R01 DC010201-04/DC/NIDCD NIH HHS; R01 EB009682/EB/NIBIB NIH HHS; R01 EB009682-01/EB/NIBIB NIH HHS; R01 HL093140-01/HL/NHLBI NIH HHS; R01 HL093140-01S1/HL/NHLBI NIH HHS; R01 HL093140-02/HL/NHLBI NIH HHS; R01 HL093140-05/HL/NHLBI NIH HHS; R01DC010201/DC/NIDCD NIH HHS; R01EB009682/EB/NIBIB NIH HHS; R01HL093140/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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