Document Detail


Depth-dependent detection of microampere currents delivered to monkey V1.
MedLine Citation:
PMID:  19519630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monkeys can detect electrical stimulation delivered to the striate cortex (area V1). We examined whether such stimulation is layer dependent. While remaining fixated on a spot of light, a rhesus monkey was required to detect a 100-ms train of electrical stimulation delivered to a site within area V1. A monkey signaled the delivery of stimulation by depressing a lever after which he was rewarded with a drop of apple juice. Control trials were interleaved during which time no stimulation was delivered and the monkey was rewarded for not depressing the lever. Biphasic pulses were delivered at 200 Hz, and the current was typically at or < 30 muA using 0.2-ms cathode-first biphasic pulses. For some experiments, the pulse duration was varied from 0.05 to 0.7 ms and anode-first pulses were used. The current threshold for detecting cathode-first pulses 50% of the time was the lowest (< 10 muA) when stimulation was delivered to the deepest layers of V1 (between 1.0 and 2.5 mm below the cortical surface). Also, the shortest chronaxies (< 0.2 ms) and the shortest latencies (< 200 ms) for detecting the stimulation were observed at these depths. Finally, anode-first pulses were most effective at evoking a detection response in superficial V1 and cathode-first pulses were most effective at evoking a detection response in deep V1 (> 1.75 mm below the cortical surface). Accordingly, the deepest layers of V1 are the most sensitive for the induction of a detection response to electrical stimulation in monkeys.
Authors:
Edward J Tehovnik; Warren M Slocum
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-23
Journal Detail:
Title:  The European journal of neuroscience     Volume:  29     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-27     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1477-89     Citation Subset:  IM    
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation*
Macaca mulatta
Microelectrodes
Neurons / physiology
Signal Detection, Psychological / physiology
Task Performance and Analysis
Time Factors
Visual Cortex / anatomy & histology,  physiology*
Grant Support
ID/Acronym/Agency:
EY014884/EY/NEI NIH HHS; R01 EY014884-05/EY/NEI NIH HHS
Comments/Corrections

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