| Depth-resolved blood oxygen saturation assessment using spectroscopic common-path Fourier domain optical coherence tomography. | |
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MedLine Citation:
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PMID: 20639176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength-distance-dependent point spread function (PSF) of OCT's. Second, to reduce the spectral speckle noise due to the highly scattering blood, we have implemented a spatial low-pass filter to the 2-D OCT dataset consisting of spectra obtained at different lateral positions. We have assessed the effectiveness of these methods using common-path OCT system. Results showed that we were able to extract unambiguous depth-resolved, SO(2)-dependent spectroscopic information from 1-D and 2-D OCT images, which could be used to accurately assess the SO(2) level. |
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Authors:
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Xuan Liu; Jin U Kang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-15 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 57 ISSN: 1558-2531 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-19 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 2572-5 Citation Subset: IM |
Affiliation:
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Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. xliu35@jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Fourier Analysis* Hemoglobins / analysis* Normal Distribution Oximetry / methods* Oxygen / blood* Oxyhemoglobins / analysis* Sheep Tomography, Optical Coherence / methods* |
| Grant Support | |
ID/Acronym/Agency:
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1R01 EB 007969-01/EB/NIBIB NIH HHS; 1R21NS063131-01A1/NS/NINDS NIH HHS; R01 EB007969-01A1/EB/NIBIB NIH HHS; R01 EB007969-03/EB/NIBIB NIH HHS; R01 EB007969-04/EB/NIBIB NIH HHS; R21 NS063131-01A1/NS/NINDS NIH HHS; R21 NS063131-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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