Document Detail

The Depth of the Olfactory Sulcus Is an Indicator of Congenital Anosmia.
MedLine Citation:
PMID:  21868619     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: In congenital anosmia, the OB and OT can be aplastic or hypoplastic. In clinical routine, these are sometimes difficult to assess. We thus wanted to investigate morphologic differences of the OS in patients with IA since birth or early childhood in comparison with controls, to investigate whether there is a depth of OS that is predictive of IA. MATERIALS AND METHODS: Within the context of a 2-center study, we investigated 36 patients with IA in comparison with 70 controls. MR imaging was performed with a standard quadrature head coil (1.5T; T1- and T2-weighted spin-echo sequences were used on the coronal plane). We assessed the depth of OS in the PPTE. RESULTS: Looking at the depth of the OS in the PPTE, we found that patients with IA had a significantly smaller OS compared with controls (P < .001). None of the healthy controls exhibited a depth of <8 mm. In patients with IA, 10 had an OS deeper than 8 mm, while 26 had an OS smaller than 8 mm. Thus, a depth of the OS less than 8 mm clearly indicates IA, with a specificity of 1 and a sensitivity of 0.72. CONCLUSIONS: In IA, the depth of the OS in the PPTE is a useful clinical indicator. Indeed, if it is ≤8 mm, it clearly indicates IA, with a specificity of 1.
C Huart; T Meusel; J Gerber; T Duprez; P Rombaux; T Hummel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-25
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  -     ISSN:  1936-959X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Otorhinolaryngology, Institute of Neurosciences, and Department of Radiology and Medical Imaging, Université Catholique de Louvain, Brussels, Belgium; and Departments of Otorhinolaryngology and Neuroradiology, Technical University of Dresden Medical School, Dresden, Germany.
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