| Depressor effect of diabetes in the spontaneously hypertensive rat: associated changes in heart performance. | |
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MedLine Citation:
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PMID: 2946385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of streptozotocin-induced diabetes (8 weeks) on the performance of perfused hearts from spontaneously hypertensive (SH) rats were compared with effects on normotensive Wistar-Kyoto (WK) and Sprague-Dawley (SD) rat hearts. Diabetes markedly decreased systolic arterial pressure (SAP) of SH rats in vivo but did not affect SAP of either of the normotensive strains. Diabetes also reduced heart size of SH and normotensive rats and reversed absolute left ventricular hypertrophy (wall-to-lumen ratios and left-to-right ventricular weight ratios) of SH rats. Heart perfusion at the end of the 8-week period revealed that diabetes (i) reduced hydraulic work at high pressure loads and efficiency of contraction (work/mu LO2 consumed) of SH rat hearts but not of WK or SD hearts, and (ii) depressed left ventricular pulse pressure development (LVPP) and contractility (LV + dP/dt) of SH hearts more extensively than it reduced these variables in either of the normotensive control groups. Effects of diabetes which were similar in hypertensive and normotensive hearts were reductions in stroke work at high volume loads and depressions in LV-dP/dt. Attendant hypothyroidism probably contributed to the reductions in SAP, heart size, LVPP, LV+ and -dP/dt, and stroke work but not to the decreased efficiency or reversal of hypertrophy of SH rat hearts. Malnutrition of SH rats, like hypothyroidism, also decreased heart size without reversing hypertrophy but had no effect on SAP and only reduced LV-dP/dt. The results show that diabetes reversed hypertrophy and selectively reduced contraction efficiency, contractility, and LVPP of SH hearts, but otherwise the effects of diabetes in hypertensive and normotensive rat strains were similar to each other.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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R L Rodgers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 64 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-22 Completed Date: 1987-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1177-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomegaly / etiology Coronary Circulation Diabetes Mellitus, Experimental / complications, physiopathology* Food Deprivation Heart / physiopathology* Hypertension / complications*, physiopathology Male Methimazole / pharmacology Myocardial Contraction Oxygen Consumption Perfusion Rats Rats, Inbred SHR* Rats, Inbred Strains* Rats, Inbred WKY Thyroxine / blood Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL 32120-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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60-56-0/Methimazole; 7488-70-2/Thyroxine |
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