| Depressive symptoms modulate the subjective and physiological response to cocaine in humans. | |
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MedLine Citation:
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PMID: 11376917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this study was to examine the relationship between the presence of subclinical depressive symptoms and physiological and subjective responses to smoked cocaine in humans. Cocaine users without major depression, who participated in various inpatient studies, received a single 0.4 mg/kg of smoked cocaine. When the relationship between the Beck Depression Inventory (BDI) scores and various subjective and physiological responses to cocaine was examined, similar trends were found. Low BDI scores of 0-7 were associated with a smaller physiological and subjective cocaine response. In contrast, BDI ranges of 8-13 were associated with enhanced cocaine response which plateaued or declined in the higher (> 14) BDI group. These group differences were not explained by sex or body weight differences among groups. The implication of these results is that the presence of depressive symptoms may affect cocaine use behavior partly by being associated with an enhanced response to cocaine. |
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Authors:
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M Sofuoglu; S Brown; D A Babb; D K Hatsukami |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 63 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-08-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Minnesota, Minneapolis, MN 55414, USA. sofuo001@tc.umn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Affect / drug effects Arousal / drug effects* Cocaine / pharmacology* Cocaine-Related Disorders / psychology* Depression / psychology* Euphoria / drug effects Female Humans Male Middle Aged Motivation Personality Inventory |
| Grant Support | |
ID/Acronym/Agency:
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MO1-RR00400/RR/NCRR NIH HHS; P-50 DA09259/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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